The sequel of It Started With A Kiss begins with Xiang Qin and Zhi Shu's wedding and honeymoon. Even after marriage, they experience problems and interferences within their marriage such as mistaken pregnancy, misunderstandings, and a run-in with a girl from Zhi Shu's past. Xiang Qin and Zhi Shu switch to medical school to become nurse and doctor. During that time, Zhi Shu meets new rivals who wish to outdo him and Xiang Qin makes four new friends, and one of them likes her and wishes to replace Zhi Shu. How will their lives turn out to be?